The polyomavirus enhancer comprises multiple functional elements
نویسندگان
چکیده
منابع مشابه
Enhancer elements
Defining transcriptional regulatory signals represents an essential step toward our understanding of eucaryotic gene expression. Analysis of genes transcribed by polymerase II has revealed a complex and interrelated set of “promoter elements.” Enhancers or activators are among the set of eucaryotic promoter elements that appear to increase transcriptional efficiency in a manner relatively indep...
متن کاملAn enhancer of recombination in polyomavirus DNA.
Previous work from this laboratory has indicated that intramolecular homologous recombination of polyomavirus (Py) DNA is dependent upon promoter structure or function. In this report, we demonstrate that Py DNA contains not two but three binding sites for transcription factor YY1, all located on the late side of viral origin of replication (ori) and the third well within the VP1 coding sequenc...
متن کاملInteraction of a nuclear factor with the polyomavirus enhancer region.
We have identified a factor present in nuclear extracts of undifferentiated F9 murine embryonal carcinoma cells that specifically interacts with the polyomavirus enhancer region. Nuclease "footprint" analysis was used to define the binding site that corresponds precisely to the boundaries of polyoma enhancer element C defined by Veldman et al. [Veldman, G. M., Lupton, S. & Kamen, R. (1985) Mol....
متن کاملThe chromatin fingerprint of gene enhancer elements.
Different cell types within a single organism are generally distinguished by strikingly different patterns of gene expression, which are dynamic throughout development and adult life. Distal enhancer elements are key drivers of spatiotemporal specificity in gene regulation. Often located tens of kilobases from their target promoters and functioning in an orientation-independent manner, the iden...
متن کاملThe interplay between multiple enhancer and silencer elements defines the pattern of decapentaplegic expression.
The product of the zygotically active decapentaplegic (dpp) gene appears to function as a morphogen that specifies positional information in the dorsal half of the Drosophila embryo. The dorsal-specific transcription of dpp is the key step in establishing a morphogen gradient. We demonstrate here that multiple regions within the second intron of the gene cooperate with one another to generate t...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1988
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.62.5.1667-1678.1988